We founded the UK Bipolar Disorder Research Network with our colleagues at Cardiff ºüÀêÊÓƵ. With support from two of the world’s leading medical research charities, the Wellcome Trust and the Stanley Medical Research Institute, more than 7500 people have already participated in our research programme, which is now the largest individual such study anywhere in the world.
We are extremely grateful to everyone who has taken part in our research – without their help the research simply would not happen. Every person who has helped brings the possibility of much-needed scientific advances nearer.
A presentation about some of the latest BDRN findings by Dr Katherine Gordon-Smith
Some of our recent BDRN publications include:
Gordon-Smith, K., Hampshire, C., Mahoney, B., Perry, A., Lewis, K. J. S., Craddock, N., Jones, I., & Jones, L. (2024). Opportunities to engage in positive activities during the COVID-19 pandemic: Perspectives of individuals with mood disorders. Journal of affective disorders, 345, 186–191.
Song, J., Jonsson, L., Lu, Y., Bergen, S. E., Karlsson, R., Smedler, E., Gordon-Smith, K., Jones, I., Jones, L., Craddock, N., Sullivan, P. F., Lichtenstein, P., Di Florio, A., & Landén, M. (2024). Key subphenotypes of bipolar disorder are differentially associated with polygenic liabilities for bipolar disorder, schizophrenia, and major depressive disorder. Molecular psychiatry, 10.1038/s41380-024-02448-1. Advance online publication.
Jonsson, L., Hörbeck, E., Primerano, A., Song, J., Karlsson, R., Smedler, E., Gordon-Smith, K., Jones, L., Craddock, N., Jones, I., Sullivan, P. F., Pålsson, E., Di Florio, A., Sparding, T., & Landén, M. (2024). Association of Occupational Dysfunction and Hospital Admissions With Different Polygenic Profiles in Bipolar Disorder. The American journal of psychiatry, 181(7), 620–629.
Allardyce, J., Cardno, A. G., Gordon-Smith, K., Jones, L., Di Florio, A., Walters, J. T. R., Holmans, P. A., Craddock, N. J., Jones, I., Owen, M. J., Escott-Price, V., & O'Donovan, M. C. (2023). Specificity of polygenic signatures across symptom dimensions in bipolar disorder: an analysis of UK Bipolar Disorder Research Network data. The lancet. Psychiatry, 10(8), 623–631.
Bolton, S., Joyce, D. W., Gordon-Smith, K., Jones, L., Jones, I., Geddes, J., & Saunders, K. E. A. (2022). Psychosocial markers of age at onset in bipolar disorder: a machine learning approach. BJPsych Open, 8(4), e133.
Richards, A. L., Cardno, A., Harold, G., Craddock, N. J., Di Florio, A., Jones, L., Gordon-Smith, K., Jones, I., Sellers, R., Walters, J. T. R., Holmans, P. A., Owen, M. J., & O'Donovan, M. C. (2022). Genetic Liabilities Differentiating Bipolar Disorder, Schizophrenia, and Major Depressive Disorder, and Phenotypic Heterogeneity in Bipolar Disorder. JAMA psychiatry, 79(10), 1032–1039.
Grotzinger, A. D., Mallard, T. T., Akingbuwa, W. A., Ip, H. F., Adams, M. J., Lewis, C. M., McIntosh, A. M., Grove, J., Dalsgaard, S., Lesch, K.-P., Strom, N., Meier, S. M., Mattheisen, M., Børglum, A. D., Mors, O., Breen, G., Mattheisen, M., Mors, O., Meier, S. M., … Nivard, M. G. (2022). Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis. Nature Genetics, 54(5), 548–559.
Palmer, D. S., Howrigan, D. P., Chapman, S. B., Adolfsson, R., Bass, N., Blackwood, D., Boks, M. P. M., Chen, C. Y., Churchhouse, C., Corvin, A. P., Craddock, N., Curtis, D., di Florio, A., Dickerson, F., Freimer, N. B., Goes, F. S., Jia, X., Jones, I., Jones, L., … Neale, B. M. (2022). Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia. Nature Genetics, 54(5), 541–547.